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Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells

INTRODUCTION: Mesenchymal stem cells (MSCs)-based therapies have had positive outcomes in animal models of cardiovascular diseases. However, the number and function of MSCs decline with age, reducing their ability to contribute to endogenous injury repair. The potential of stem cells to restore dama...

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Detalles Bibliográficos
Autores principales: Xia, Wenzheng, Zhang, Fengyun, Xie, Congying, Jiang, Miaomiao, Hou, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453287/
https://www.ncbi.nlm.nih.gov/pubmed/25896286
http://dx.doi.org/10.1186/s13287-015-0076-3