Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer

BACKGROUND: Telomeres are TTAGGG tandem repeats capping chromosomal ends and partially controlled by the telomerase enzyme. The EGFR pathway putatively regulates telomerase function, prompting an investigation of telomere length (TL) and its association with anti-epidermal growth factor receptor (EG...

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Detalles Bibliográficos
Autores principales: Augustine, T A, Baig, M, Sood, A, Budagov, T, Atzmon, G, Mariadason, J M, Aparo, S, Maitra, R, Goel, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453445/
https://www.ncbi.nlm.nih.gov/pubmed/25412235
http://dx.doi.org/10.1038/bjc.2014.561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453445/
https://www.ncbi.nlm.nih.gov/pubmed/25412235
http://dx.doi.org/10.1038/bjc.2014.561

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