Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells

BACKGROUND: Transcriptional repression is a key mechanism driving leukaemogenesis. In acute promyelocytic leukaemia (APL), the fusion protein promyelocytic leukaemia-retinoic acid receptor-α fusion (PML-RARα) recruits transcriptional repressors to myeloid differentiation genes. All-trans-retinoic ac...

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Detalles Bibliográficos
Autores principales: Hennig, D, Müller, S, Wichmann, C, Drube, S, Pietschmann, K, Pelzl, L, Grez, M, Bug, G, Heinzel, T, Krämer, O H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453449/
https://www.ncbi.nlm.nih.gov/pubmed/25514379
http://dx.doi.org/10.1038/bjc.2014.589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453449/
https://www.ncbi.nlm.nih.gov/pubmed/25514379
http://dx.doi.org/10.1038/bjc.2014.589

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