A Group A Streptococcus ADP-Ribosyltransferase Toxin Stimulates a Protective Interleukin 1β-Dependent Macrophage Immune Response

The M1T1 clone of group A Streptococcus (GAS) is associated with severe invasive infections, including necrotizing fasciitis and septicemia. During invasive M1T1 GAS disease, mutations in the covRS regulatory system led to upregulation of an ADP-ribosyltransferase, SpyA. Surprisingly, a GAS ΔspyA mu...

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Detalles Bibliográficos
Autores principales: Lin, Ann E., Beasley, Federico C., Keller, Nadia, Hollands, Andrew, Urbano, Rodolfo, Troemel, Emily R., Hoffman, Hal M., Nizet, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453525/
https://www.ncbi.nlm.nih.gov/pubmed/25759502
http://dx.doi.org/10.1128/mBio.00133-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453525/
https://www.ncbi.nlm.nih.gov/pubmed/25759502
http://dx.doi.org/10.1128/mBio.00133-15

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