Recoding of the Vesicular Stomatitis Virus L Gene by Computer-Aided Design Provides a Live, Attenuated Vaccine Candidate

Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes regardless of codon bias. The effect of an individual codon pair change is usually s...

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Detalles Bibliográficos
Autores principales: Wang, Bingyin, Yang, Chen, Tekes, Gergely, Mueller, Steffen, Paul, Aniko, Whelan, Sean P. J., Wimmer, Eckard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453547/
https://www.ncbi.nlm.nih.gov/pubmed/25827413
http://dx.doi.org/10.1128/mBio.00237-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453547/
https://www.ncbi.nlm.nih.gov/pubmed/25827413
http://dx.doi.org/10.1128/mBio.00237-15

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