Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma

BACKGROUND: Epigenetic therapy using histone deacetylase inhibitors (HDACi) has shown promise in clinical trials for the treatment of human malignancies. In addition to the immediate effects on the tumour cell growth, HDACi upregulates the expression of MHC class I-related chain molecules A and B (M...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, H, Lan, P, Hou, Z, Guan, Y, Zhang, J, Xu, W, Tian, Z, Zhang, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453603/
https://www.ncbi.nlm.nih.gov/pubmed/25393367
http://dx.doi.org/10.1038/bjc.2014.547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453603/
https://www.ncbi.nlm.nih.gov/pubmed/25393367
http://dx.doi.org/10.1038/bjc.2014.547

Ejemplares similares