MRI reveals the in vivo cellular and vascular response to BEZ235 in ovarian cancer xenografts with different PI3-kinase pathway activity

BACKGROUND: The phosphoinositide-3 kinase (PI3K) pathway is an attractive therapeutic target. However, difficulty in predicting therapeutic response limits the clinical implementation of PI3K inhibitors. This study evaluates the utility of clinically relevant magnetic resonance imaging (MRI) biomark...

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Detalles Bibliográficos
Autores principales: Cebulla, J, Huuse, E M, Pettersen, K, van der Veen, A, Kim, E, Andersen, S, Prestvik, W S, Bofin, A M, Pathak, A P, Bjørkøy, G, Bathen, T F, Moestue, S A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453650/
https://www.ncbi.nlm.nih.gov/pubmed/25535727
http://dx.doi.org/10.1038/bjc.2014.628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453650/
https://www.ncbi.nlm.nih.gov/pubmed/25535727
http://dx.doi.org/10.1038/bjc.2014.628

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