Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours

BACKGROUND: Effective vascular normalisation following vascular endothelial growth factor (VEGF) inhibition is associated with endothelial cell regression leaving empty basement membrane sleeves (BMS). These long-lived BMS permit the rapid regrowth of tumour vasculature upon treatment cessation and...

Descripción completa

Detalles Bibliográficos
Autores principales: Coutelle, O, Schiffmann, L M, Liwschitz, M, Brunold, M, Goede, V, Hallek, M, Kashkar, H, Hacker, U T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453651/
https://www.ncbi.nlm.nih.gov/pubmed/25562438
http://dx.doi.org/10.1038/bjc.2014.629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453651/
https://www.ncbi.nlm.nih.gov/pubmed/25562438
http://dx.doi.org/10.1038/bjc.2014.629

Ejemplares similares