The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer

BACKGROUND: Men with a BRCA2 mutation face an increased risk of prostate cancer. These cancers tend to have an aggressive nature and it has not yet been demonstrated that regular screening of BRCA2 carriers is associated with improved survival. METHODS: We identified 4187 men who underwent a prostat...

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Detalles Bibliográficos
Autores principales: Akbari, M R, Wallis, C J D, Toi, A, Trachtenberg, J, Sun, P, Narod, S A, Nam, R K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453856/
https://www.ncbi.nlm.nih.gov/pubmed/25101567
http://dx.doi.org/10.1038/bjc.2014.428
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author Akbari, M R
Wallis, C J D
Toi, A
Trachtenberg, J
Sun, P
Narod, S A
Nam, R K
author_facet Akbari, M R
Wallis, C J D
Toi, A
Trachtenberg, J
Sun, P
Narod, S A
Nam, R K
author_sort Akbari, M R
collection PubMed
description BACKGROUND: Men with a BRCA2 mutation face an increased risk of prostate cancer. These cancers tend to have an aggressive nature and it has not yet been demonstrated that regular screening of BRCA2 carriers is associated with improved survival. METHODS: We identified 4187 men who underwent a prostate cancer biopsy for an elevated PSA or an abnormal digital rectal examination between 1998 and 2010. We screened the BRCA2 gene in its entirety for mutations and we followed the men for death from prostate cancer until December 2012. RESULTS: The 12-year prostate cancer-specific survival rate was 94.3% for men without a BRCA2 mutation and was 61.8% for men with a mutation (P<10(−4); log-rank test). CONCLUSIONS: The survival of men with screen-detected prostate cancer and a BRCA2 mutation is much poorer than expected.
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spelling pubmed-44538562015-09-09 The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer Akbari, M R Wallis, C J D Toi, A Trachtenberg, J Sun, P Narod, S A Nam, R K Br J Cancer Genetics and Genomics BACKGROUND: Men with a BRCA2 mutation face an increased risk of prostate cancer. These cancers tend to have an aggressive nature and it has not yet been demonstrated that regular screening of BRCA2 carriers is associated with improved survival. METHODS: We identified 4187 men who underwent a prostate cancer biopsy for an elevated PSA or an abnormal digital rectal examination between 1998 and 2010. We screened the BRCA2 gene in its entirety for mutations and we followed the men for death from prostate cancer until December 2012. RESULTS: The 12-year prostate cancer-specific survival rate was 94.3% for men without a BRCA2 mutation and was 61.8% for men with a mutation (P<10(−4); log-rank test). CONCLUSIONS: The survival of men with screen-detected prostate cancer and a BRCA2 mutation is much poorer than expected. Nature Publishing Group 2014-09-09 2014-08-07 /pmc/articles/PMC4453856/ /pubmed/25101567 http://dx.doi.org/10.1038/bjc.2014.428 Text en Copyright © 2014 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Genetics and Genomics
Akbari, M R
Wallis, C J D
Toi, A
Trachtenberg, J
Sun, P
Narod, S A
Nam, R K
The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer
title The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer
title_full The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer
title_fullStr The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer
title_full_unstemmed The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer
title_short The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer
title_sort impact of a brca2 mutation on mortality from screen-detected prostate cancer
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453856/
https://www.ncbi.nlm.nih.gov/pubmed/25101567
http://dx.doi.org/10.1038/bjc.2014.428
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