Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion

BACKGROUND: Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine...

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Detalles Bibliográficos
Autores principales: Hassona, Y, Cirillo, N, Heesom, K, Parkinson, E K, Prime, S S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453858/
https://www.ncbi.nlm.nih.gov/pubmed/25117810
http://dx.doi.org/10.1038/bjc.2014.438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453858/
https://www.ncbi.nlm.nih.gov/pubmed/25117810
http://dx.doi.org/10.1038/bjc.2014.438

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