Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy

BACKGROUND: Autophagy allows recycling of cellular components and may facilitate cell survival after chemotherapy. Pantoprazole inhibits proton pumps and is reported to inhibit autophagy. Here we evaluate the effects of pantoprazole to modify cytotoxicity of the anticancer drug docetaxel, and underl...

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Detalles Bibliográficos
Autores principales: Tan, Q, Joshua, A M, Saggar, J K, Yu, M, Wang, M, Kanga, N, Zhang, J Y, Chen, X, Wouters, B G, Tannock, I F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453951/
https://www.ncbi.nlm.nih.gov/pubmed/25647012
http://dx.doi.org/10.1038/bjc.2015.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453951/
https://www.ncbi.nlm.nih.gov/pubmed/25647012
http://dx.doi.org/10.1038/bjc.2015.17

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