p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo

The goal of the present study was to compare hepatic toxicogenomic signatures across in vitro and in vivo mouse models following exposure to acetaminophen (APAP) or its relatively nontoxic regioisomer 3′-hydroxyacetanilide (AMAP). Two different Affymetrix microarray platforms and one Agilent Oligonu...

Descripción completa

Detalles Bibliográficos
Autores principales: Stamper, Brendan D, Garcia, Michael L, Nguyen, Duy Q, Beyer, Richard P, Bammler, Theo K, Farin, Frederico M, Kavanagh, Terrance J, Nelson, Sidney D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454132/
https://www.ncbi.nlm.nih.gov/pubmed/26056430
http://dx.doi.org/10.4137/GRSB.S25388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454132/
https://www.ncbi.nlm.nih.gov/pubmed/26056430
http://dx.doi.org/10.4137/GRSB.S25388

Ejemplares similares