Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response

Smac (second mitochondria-derived activator of caspase) mimetics are considered as promising anticancer therapeutics and used to induce apoptosis by antagonizing inhibitor of apoptosis proteins, which are often abundantly expressed in cancer cells. Here, we identify interferon regulatory factor 1 (I...

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Detalles Bibliográficos
Autores principales: Eckhardt, I, Weigert, A, Fulda, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454156/
https://www.ncbi.nlm.nih.gov/pubmed/25501823
http://dx.doi.org/10.1038/cddis.2014.498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454156/
https://www.ncbi.nlm.nih.gov/pubmed/25501823
http://dx.doi.org/10.1038/cddis.2014.498

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