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Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response
Smac (second mitochondria-derived activator of caspase) mimetics are considered as promising anticancer therapeutics and used to induce apoptosis by antagonizing inhibitor of apoptosis proteins, which are often abundantly expressed in cancer cells. Here, we identify interferon regulatory factor 1 (I...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454156/ https://www.ncbi.nlm.nih.gov/pubmed/25501823 http://dx.doi.org/10.1038/cddis.2014.498 |