An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina

Recent studies on the endoplasmic reticulum stress have shown that the unfolded protein response (UPR) is involved in the pathogenesis of inherited retinal degeneration caused by mutant rhodopsin. However, the main question of whether UPR activation actually triggers retinal degeneration remains to...

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Detalles Bibliográficos
Autores principales: Rana, T, Shinde, V M, Starr, C R, Kruglov, A A, Boitet, E R, Kotla, P, Zolotukhin, S, Gross, A K, Gorbatyuk, M S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454166/
https://www.ncbi.nlm.nih.gov/pubmed/25522272
http://dx.doi.org/10.1038/cddis.2014.539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454166/
https://www.ncbi.nlm.nih.gov/pubmed/25522272
http://dx.doi.org/10.1038/cddis.2014.539

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