The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway

Loss of the mitochondrial protease activity of Omi causes mitochondrial dysfunction, neurodegeneration with parkinsonian features and premature death in mnd2 (motor neuron degeneration 2) mice. However, the detailed mechanisms underlying this pathology remain largely unknown. Here, we report that Om...

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Detalles Bibliográficos
Autores principales: Xu, R, Hu, Q, Ma, Q, Liu, C, Wang, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454303/
https://www.ncbi.nlm.nih.gov/pubmed/25118933
http://dx.doi.org/10.1038/cddis.2014.328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454303/
https://www.ncbi.nlm.nih.gov/pubmed/25118933
http://dx.doi.org/10.1038/cddis.2014.328

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