Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease

To develop allopregnanolone as a therapeutic for Alzheimer’s disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes. Subcutaneous, topical (transdermal and intranasal), intramuscular, and intravenous allopregnanolone were b...

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Detalles Bibliográficos
Autores principales: Irwin, Ronald W., Solinsky, Christine M., Loya, Carlos M., Salituro, Francesco G., Rodgers, Kathleen E., Bauer, Gerhard, Rogawski, Michael A., Brinton, Roberta Diaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454520/
https://www.ncbi.nlm.nih.gov/pubmed/26039057
http://dx.doi.org/10.1371/journal.pone.0128313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454520/
https://www.ncbi.nlm.nih.gov/pubmed/26039057
http://dx.doi.org/10.1371/journal.pone.0128313

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