PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation

Crosstalk between the phosphatidylinositol 3-kinase (PI3K) and the transforming growth factor-β signalling pathways play an important role in regulating many cellular functions. However, the molecular mechanisms underpinning this crosstalk remain unclear. Here, we report that PI3K signalling antagon...

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Detalles Bibliográficos
Autores principales: Yu, Jason S. L., Ramasamy, Thamil Selvee, Murphy, Nick, Holt, Marie K., Czapiewski, Rafal, Wei, Shi-Khai, Cui, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455068/
https://www.ncbi.nlm.nih.gov/pubmed/25998442
http://dx.doi.org/10.1038/ncomms8212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455068/
https://www.ncbi.nlm.nih.gov/pubmed/25998442
http://dx.doi.org/10.1038/ncomms8212

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