LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

Mammalian target of rapamycin 1 (mTORC1), a master regulator of cellular growth, is activated downstream of growth factors, energy signalling and intracellular essential amino acids (EAAs) such as Leu. mTORC1 activation occurs at the lysosomal membrane, and involves V-ATPase stimulation by intra-lys...

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Detalles Bibliográficos
Autores principales: Milkereit, Ruth, Persaud, Avinash, Vanoaica, Liviu, Guetg, Adriano, Verrey, Francois, Rotin, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455107/
https://www.ncbi.nlm.nih.gov/pubmed/25998567
http://dx.doi.org/10.1038/ncomms8250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455107/
https://www.ncbi.nlm.nih.gov/pubmed/25998567
http://dx.doi.org/10.1038/ncomms8250

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