Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity

The ubiquitin-proteasome system (UPS) is the primary mechanism by which intracellular proteins, transcription factors, and many proteotoxic proteins with aggregation-prone structures are degraded. The UPS is reportedly downregulated in various neurodegenerative disorders, with increased proteasome a...

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Detalles Bibliográficos
Autores principales: Lee, Jung Hoon, Shin, Seung Kyun, Jiang, Yanxialei, Choi, Won Hoon, Hong, Chaesun, Kim, Dong-Eun, Lee, Min Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455164/
https://www.ncbi.nlm.nih.gov/pubmed/26041011
http://dx.doi.org/10.1038/srep10757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455164/
https://www.ncbi.nlm.nih.gov/pubmed/26041011
http://dx.doi.org/10.1038/srep10757

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