Mapping Small Effect Mutations in Saccharomyces cerevisiae: Impacts of Experimental Design and Mutational Properties

Genetic variants identified by mapping are biased toward large phenotypic effects because of methodologic challenges for detecting genetic variants with small phenotypic effects. Recently, bulk segregant analysis combined with next-generation sequencing (BSA-seq) was shown to be a powerful and cost-...

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Detalles Bibliográficos
Autores principales: Duveau, Fabien, Metzger, Brian P. H., Gruber, Jonathan D., Mack, Katya, Sood, Natasha, Brooks, Tiffany E., Wittkopp, Patricia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455770/
https://www.ncbi.nlm.nih.gov/pubmed/24789747
http://dx.doi.org/10.1534/g3.114.011783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455770/
https://www.ncbi.nlm.nih.gov/pubmed/24789747
http://dx.doi.org/10.1534/g3.114.011783

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