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mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia

Chronic pain is a major public health problem with limited treatment options. Opioids remain a routine treatment for chronic pain, but extended exposure to opioid therapy can produce opioid tolerance and hyperalgesia. Although the mechanisms underlying chronic pain, opioid-induced tolerance, and opi...

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Detalles Bibliográficos
Autores principales: Lutz, Brianna Marie, Nia, Sam, Xiong, Ming, Tao, Yuan-Xiang, Bekker, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455918/
https://www.ncbi.nlm.nih.gov/pubmed/26024835
http://dx.doi.org/10.1186/s12990-015-0030-5