Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C-terminus

The molecular circadian clock in mammals is generated from transcriptional activation by the bHLH-PAS transcription factor CLOCK–BMAL1 and subsequent repression by PERIOD and CRYPTOCHROME (CRY). The mechanism by which CRYs repress CLOCK–BMAL1 to close the negative feedback loop and generate 24-hour...

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Detalles Bibliográficos
Autores principales: Xu, Haiyan, Gustafson, Chelsea L., Sammons, Patrick J., Khan, Sanjoy K., Parsley, Nicole C., Ramanathan, Chidambaram, Lee, Hsiau-Wei, Liu, Andrew C., Partch, Carrie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456216/
https://www.ncbi.nlm.nih.gov/pubmed/25961797
http://dx.doi.org/10.1038/nsmb.3018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456216/
https://www.ncbi.nlm.nih.gov/pubmed/25961797
http://dx.doi.org/10.1038/nsmb.3018

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