Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways. Activating mutations in Shp2 are commonly associated with juvenile myelomonocytic leukemia (JMML) but are not as well defined in other neoplasms. Here we report that Shp2 mutations occur in hu...

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Detalles Bibliográficos
Autores principales: Chen, Lili, Chen, Wei, Mysliwski, Maria, Serio, Justin, Ropa, James, Abulwerdi, Fardokht A., Chan, Rebecca J., Patel, Jay P., Tallman, Martin S., Paietta, Elisabeth, Melnick, Ari, Levine, Ross L., Abdel-Wahab, Omar, Nikolovska-Coleska, Zaneta, Muntean, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456293/
https://www.ncbi.nlm.nih.gov/pubmed/25650089
http://dx.doi.org/10.1038/leu.2015.18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456293/
https://www.ncbi.nlm.nih.gov/pubmed/25650089
http://dx.doi.org/10.1038/leu.2015.18

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