mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)

In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis. Here, we identify the mammalian target of rapamycin compl...

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Detalles Bibliográficos
Autores principales: Feng, Daorong, Youn, Dou Yeon, Zhao, Xiaoping, Gao, Yanguang, Quinn, William J., Xiaoli, Alus M., Sun, Yan, Birnbaum, Morris J., Pessin, Jeffrey E., Yang, Fajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456374/
https://www.ncbi.nlm.nih.gov/pubmed/26042770
http://dx.doi.org/10.1371/journal.pone.0126240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456374/
https://www.ncbi.nlm.nih.gov/pubmed/26042770
http://dx.doi.org/10.1371/journal.pone.0126240

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