Leveraging Identity-by-Descent for Accurate Genotype Inference in Family Sequencing Data

Sequencing family DNA samples provides an attractive alternative to population based designs to identify rare variants associated with human disease due to the enrichment of causal variants in pedigrees. Previous studies showed that genotype calling accuracy can be improved by modeling family relate...

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Detalles Bibliográficos
Autores principales: Li, Bingshan, Wei, Qiang, Zhan, Xiaowei, Zhong, Xue, Chen, Wei, Li, Chun, Haines, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456389/
https://www.ncbi.nlm.nih.gov/pubmed/26043085
http://dx.doi.org/10.1371/journal.pgen.1005271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456389/
https://www.ncbi.nlm.nih.gov/pubmed/26043085
http://dx.doi.org/10.1371/journal.pgen.1005271

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