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Leveraging Identity-by-Descent for Accurate Genotype Inference in Family Sequencing Data
Sequencing family DNA samples provides an attractive alternative to population based designs to identify rare variants associated with human disease due to the enrichment of causal variants in pedigrees. Previous studies showed that genotype calling accuracy can be improved by modeling family relate...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456389/ https://www.ncbi.nlm.nih.gov/pubmed/26043085 http://dx.doi.org/10.1371/journal.pgen.1005271 |