A functional link between the co-translational protein translocation pathway and the UPR

Upon endoplasmic reticulum (ER) stress, the transmembrane endoribonuclease Ire1α performs mRNA cleavage reactions to increase the ER folding capacity. It is unclear how the low abundant Ire1α efficiently finds and cleaves the majority of mRNAs at the ER membrane. Here, we reveal that Ire1α forms a c...

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Detalles Bibliográficos
Autores principales: Plumb, Rachel, Zhang, Zai-Rong, Appathurai, Suhila, Mariappan, Malaiyalam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456659/
https://www.ncbi.nlm.nih.gov/pubmed/25993558
http://dx.doi.org/10.7554/eLife.07426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456659/
https://www.ncbi.nlm.nih.gov/pubmed/25993558
http://dx.doi.org/10.7554/eLife.07426

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