Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A

The nucleolus, whose primary function is ribosome biogenesis, plays an essential role in p53 activation. Ribosome biogenesis is inhibited in response to cellular stress and several nucleolar proteins translocate from the nucleolus to the nucleoplasm, where they activate p53. In this study, we analys...

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Detalles Bibliográficos
Autores principales: Kumazawa, Takuya, Nishimura, Kazuho, Katagiri, Naohiro, Hashimoto, Sayaka, Hayashi, Yuki, Kimura, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456663/
https://www.ncbi.nlm.nih.gov/pubmed/26044764
http://dx.doi.org/10.1038/srep10854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456663/
https://www.ncbi.nlm.nih.gov/pubmed/26044764
http://dx.doi.org/10.1038/srep10854

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