Ten modifiers of BRCA1 penetrance validated in a Norwegian series

BACKGROUND: Common genetic variants have been shown to modify BRCA1 penetrance. The aim of this study was to validate these reports in a special cohort of Norwegian BRCA1 mutation carriers that were selected for their extreme age of onset of disease. METHODS: The ten variants rs13387042, rs3803662,...

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Detalles Bibliográficos
Autores principales: Heramb, Cecilie, Ekstrøm, Per Olaf, Tharmaratnam, Kukatharmini, Hovig, Eivind, Møller, Pål, Mæhle, Lovise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456774/
https://www.ncbi.nlm.nih.gov/pubmed/26052370
http://dx.doi.org/10.1186/s13053-015-0035-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456774/
https://www.ncbi.nlm.nih.gov/pubmed/26052370
http://dx.doi.org/10.1186/s13053-015-0035-0

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