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Ten modifiers of BRCA1 penetrance validated in a Norwegian series
BACKGROUND: Common genetic variants have been shown to modify BRCA1 penetrance. The aim of this study was to validate these reports in a special cohort of Norwegian BRCA1 mutation carriers that were selected for their extreme age of onset of disease. METHODS: The ten variants rs13387042, rs3803662,...
Autores principales: | Heramb, Cecilie, Ekstrøm, Per Olaf, Tharmaratnam, Kukatharmini, Hovig, Eivind, Møller, Pål, Mæhle, Lovise |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456774/ https://www.ncbi.nlm.nih.gov/pubmed/26052370 http://dx.doi.org/10.1186/s13053-015-0035-0 |
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