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Animal Models of Interferon Signature Positive Lupus
Human lupus is strongly associated with a gene expression signature characterized by over-expression of Type I interferon-regulated genes. A strong interferon signature generally is not seen in the standard mouse models of lupus, despite considerable evidence for the involvement of toll-like recepto...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456949/ https://www.ncbi.nlm.nih.gov/pubmed/26097482 http://dx.doi.org/10.3389/fimmu.2015.00291 |
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author | Zhuang, Haoyang Szeto, Christopher Han, Shuhong Yang, Lijun Reeves, Westley H. |
author_facet | Zhuang, Haoyang Szeto, Christopher Han, Shuhong Yang, Lijun Reeves, Westley H. |
author_sort | Zhuang, Haoyang |
collection | PubMed |
description | Human lupus is strongly associated with a gene expression signature characterized by over-expression of Type I interferon-regulated genes. A strong interferon signature generally is not seen in the standard mouse models of lupus, despite considerable evidence for the involvement of toll-like receptor-driven interferon production. In contrast, pristane-induced lupus exhibits a prominent TLR7-dependent interferon signature. Importantly, genetic disorders with dysregulated interferon production in both human beings and mice cause severe autoinflammatory diseases but not the typical manifestations of lupus, suggesting that interferon over-production is insufficient to cause systemic lupus erythematosus itself. Single-gene models in mice suggest that lupus-like disease may result from abnormalities in B-cell activation and the clearance of dead cells. Pristane may mimic human systemic lupus erythematosus by causing synergistic abnormalities in interferon production along with defective clearance of apoptotic cells and over-active B-cell signaling. |
format | Online Article Text |
id | pubmed-4456949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44569492015-06-19 Animal Models of Interferon Signature Positive Lupus Zhuang, Haoyang Szeto, Christopher Han, Shuhong Yang, Lijun Reeves, Westley H. Front Immunol Immunology Human lupus is strongly associated with a gene expression signature characterized by over-expression of Type I interferon-regulated genes. A strong interferon signature generally is not seen in the standard mouse models of lupus, despite considerable evidence for the involvement of toll-like receptor-driven interferon production. In contrast, pristane-induced lupus exhibits a prominent TLR7-dependent interferon signature. Importantly, genetic disorders with dysregulated interferon production in both human beings and mice cause severe autoinflammatory diseases but not the typical manifestations of lupus, suggesting that interferon over-production is insufficient to cause systemic lupus erythematosus itself. Single-gene models in mice suggest that lupus-like disease may result from abnormalities in B-cell activation and the clearance of dead cells. Pristane may mimic human systemic lupus erythematosus by causing synergistic abnormalities in interferon production along with defective clearance of apoptotic cells and over-active B-cell signaling. Frontiers Media S.A. 2015-06-05 /pmc/articles/PMC4456949/ /pubmed/26097482 http://dx.doi.org/10.3389/fimmu.2015.00291 Text en Copyright © 2015 Zhuang, Szeto, Han, Yang and Reeves. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhuang, Haoyang Szeto, Christopher Han, Shuhong Yang, Lijun Reeves, Westley H. Animal Models of Interferon Signature Positive Lupus |
title | Animal Models of Interferon Signature Positive Lupus |
title_full | Animal Models of Interferon Signature Positive Lupus |
title_fullStr | Animal Models of Interferon Signature Positive Lupus |
title_full_unstemmed | Animal Models of Interferon Signature Positive Lupus |
title_short | Animal Models of Interferon Signature Positive Lupus |
title_sort | animal models of interferon signature positive lupus |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456949/ https://www.ncbi.nlm.nih.gov/pubmed/26097482 http://dx.doi.org/10.3389/fimmu.2015.00291 |
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