Binding Affinities Controlled by Shifting Conformational Equilibria: Opportunities and Limitations

Conformational selection is an established mechanism in molecular recognition. Despite its power to explain binding events, it is hardly used in protein/ligand design to modulate molecular recognition. Here, we explore the opportunities and limitations of design by conformational selection. Using ap...

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Detalles Bibliográficos
Autores principales: Michielssens, Servaas, de Groot, Bert L., Grubmüller, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2015
Materias:
Proteins and Nucleic Acids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457000/
https://www.ncbi.nlm.nih.gov/pubmed/25992736
http://dx.doi.org/10.1016/j.bpj.2015.04.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457000/
https://www.ncbi.nlm.nih.gov/pubmed/25992736
http://dx.doi.org/10.1016/j.bpj.2015.04.012

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