The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67(tm1Dgen/H1) kno...

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Detalles Bibliográficos
Autores principales: Abdelhamed, Zakia A., Natarajan, Subaashini, Wheway, Gabrielle, Inglehearn, Christopher F., Toomes, Carmel, Johnson, Colin A., Jagger, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457033/
https://www.ncbi.nlm.nih.gov/pubmed/26035863
http://dx.doi.org/10.1242/dmm.019083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457033/
https://www.ncbi.nlm.nih.gov/pubmed/26035863
http://dx.doi.org/10.1242/dmm.019083

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