Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells

Trinucleotide repeat expansion disorders (TRED) are caused by genomic expansions of trinucleotide repeats, such as CTG and CAG. These expanded repeats are unstable in germline and somatic cells, with potential consequences for disease severity. Previous studies have demonstrated the involvement of D...

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Detalles Bibliográficos
Autores principales: Nakatani, Rie, Nakamori, Masayuki, Fujimura, Harutoshi, Mochizuki, Hideki, Takahashi, Masanori P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457148/
https://www.ncbi.nlm.nih.gov/pubmed/26047474
http://dx.doi.org/10.1038/srep11020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457148/
https://www.ncbi.nlm.nih.gov/pubmed/26047474
http://dx.doi.org/10.1038/srep11020

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