Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice

We tested whether a high fat diet (HFD) containing the inflammatory dietary fatty acid palmitate or insulin deficient diabetes altered the remodeling of atherosclerotic plaques in LDL receptor knockout (Ldlr(-/-)) mice. Cholesterol reduction was achieved by using a helper-dependent adenovirus (HDAd)...

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Detalles Bibliográficos
Autores principales: Willecke, Florian, Yuan, Chujun, Oka, Kazuhiro, Chan, Lawrence, Hu, Yunying, Barnhart, Shelley, Bornfeldt, Karin E., Goldberg, Ira J., Fisher, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457481/
https://www.ncbi.nlm.nih.gov/pubmed/26046657
http://dx.doi.org/10.1371/journal.pone.0128996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457481/
https://www.ncbi.nlm.nih.gov/pubmed/26046657
http://dx.doi.org/10.1371/journal.pone.0128996

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