Elucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2

Numerous biomolecular interactions involve unstructured protein regions, but how to exploit such interactions to enhance the affinity of a lead molecule in the context of rational drug design remains uncertain. Here clarification was sought for cases where interactions of different ligands with the...

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Detalles Bibliográficos
Autores principales: Bueren-Calabuig, Juan A., Michel, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457491/
https://www.ncbi.nlm.nih.gov/pubmed/26046940
http://dx.doi.org/10.1371/journal.pcbi.1004282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457491/
https://www.ncbi.nlm.nih.gov/pubmed/26046940
http://dx.doi.org/10.1371/journal.pcbi.1004282

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