Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase

Oncogenic mutation of the RET receptor tyrosine kinase is observed in several human malignancies. Here, we describe three novel type II RET tyrosine kinase inhibitors (TKI), ALW-II-41-27, XMD15-44 and HG-6-63-01, that inhibit the cellular activity of oncogenic RET mutants at two digit nanomolar conc...

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Detalles Bibliográficos
Autores principales: Moccia, Marialuisa, Liu, Qingsong, Guida, Teresa, Federico, Giorgia, Brescia, Annalisa, Zhao, Zheng, Choi, Hwan Geun, Deng, Xianming, Tan, Li, Wang, Jinhua, Billaud, Marc, Gray, Nathanael S., Carlomagno, Francesca, Santoro, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457528/
https://www.ncbi.nlm.nih.gov/pubmed/26046350
http://dx.doi.org/10.1371/journal.pone.0128364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457528/
https://www.ncbi.nlm.nih.gov/pubmed/26046350
http://dx.doi.org/10.1371/journal.pone.0128364

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