Cargando…

Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium

Retinal endothelial cell dysfunction is believed to play a key role in the etiology and pathogenesis of diabetic retinopathy. Numerous studies have shown that TRPV4 channels are critically involved in maintaining normal endothelial cell function. In the current paper, we demonstrate that TRPV4 is fu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Monaghan, Kevin, McNaughten, Jennifer, McGahon, Mary K., Kelly, Catriona, Kyle, Daniel, Yong, Phaik Har, McGeown, J. Graham, Curtis, Tim M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457535/ https://www.ncbi.nlm.nih.gov/pubmed/26047504 http://dx.doi.org/10.1371/journal.pone.0128359

Ejemplares similares

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
por: Curtis, Tim M., et al.
Publicado: (2018)

Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle
por: McGahon, Mary K., et al.
Publicado: (2007)

Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
por: O’Hare, Michael, et al.
Publicado: (2022)

Single-cell transcriptomic profiling provides insights into retinal endothelial barrier properties
por: Watson, Mark I., et al.
Publicado: (2020)

Fast Retinal Vessel Detection and Measurement Using Wavelets and Edge Location Refinement
por: Bankhead, Peter, et al.
Publicado: (2012)

Ca(2+)-sparks constitute elementary building blocks for global Ca(2+)-signals in myocytes of retinal arterioles
por: Tumelty, James, et al.
Publicado: (2007)

Automated Detection and Measurement of Isolated Retinal Arterioles by a Combination of Edge Enhancement and Cost Analysis
por: Fernández, José A., et al.
Publicado: (2014)

A recipe for transplantation.
por: McGeown, M. G.
Publicado: (1984)

Renal replacement therapy in Ireland--the Belfast experience. Based on the 2nd J Creery Ferguson Memorial Lecture of the Royal College of Physicians of Ireland on the occasion of the bicentenary of the Royal Victoria Hospital--7th March 1997.
por: McGeown, M. G.
Publicado: (2000)

Current ethical issues in organ transplantation.
por: McGeown, M. G.
Publicado: (1994)

Bacterial Endocarditis: The Process of Healing
por: McGeown, Mary Graham
Publicado: (1954)

Can Renal Calculi be Prevented?
por: McGeown, Mary G.
Publicado: (1955)

The thirtieth anniversary of pre-hospital coronary care in Belfast.
por: McGeown, M. G.
Publicado: (1996)

36 years of renal services at the Belfast City Hospital: looking back.
por: McGeown, M. G.
Publicado: (1996)

Transplantation.
por: McGeown, M. G.
Publicado: (1987)

Dialysis and transplantation: problems for the future.
por: McGeown, M. G.
Publicado: (1986)

Twenty-first birthday of the Renal Unit at the Belfast City Hospital.
por: McGeown, M. G.
Publicado: (1981)

Seeing is believing! Imaging Ca(2+)-signalling events in living cells
por: McGeown, J Graham
Publicado: (2010)

Calibration of confidence and assessed clinical skills competence in undergraduate paediatric OSCE scenarios: a mixed methods study
por: O’Donoghue, Dara, et al.
Publicado: (2018)

Effect of plasma transfusion on serum amyloid A concentration in healthy neonatal foals and foals with failure of transfer of passive immunity
por: Palmisano, Megan, et al.
Publicado: (2023)

Renal Lesions in Choline Deficiency in Rats
por: Johnston, Nafra, et al.
Publicado: (1957)

“It’s a waiting game” a qualitative study of the experience of carers of patients who require an alternate level of care
por: Kuluski, Kerry, et al.
Publicado: (2017)

Emergency Animal Boarding: A Social Return on Investment
por: Ma, Gemma C., et al.
Publicado: (2023)

The treatment of paraquat poisoning: three cases of recovery.
por: Douglas, J. F., et al.
Publicado: (1973)

Quality assurance in 3D-printing: A dimensional accuracy study of patient-specific 3D-printed vascular anatomical models
por: Nguyen, Philip, et al.
Publicado: (2023)

One hundred kidney transplants in the Belfast City Hospital.
por: McGeown, M. G., et al.
Publicado: (1977)

Prolonged cholinergic enrichment influences regional cortical activation in early Alzheimer’s disease
por: McGeown, William J, et al.
Publicado: (2008)

The Pleiotropic Effects of Simvastatin on Retinal Microvascular Endothelium Has Important Implications for Ischaemic Retinopathies
por: Medina, Reinhold J., et al.
Publicado: (2008)

How do patient and care experience data inform policy and practice? Insights from the Irish National Care Experience Programme
por: Hyland, D, et al.
Publicado: (2023)

Endothelium in Coronary Macrovascular and Microvascular Diseases
por: Godo, Shigeo, et al.
Publicado: (2021)

Aging and the number sense: preserved basic non-symbolic numerical processing and enhanced basic symbolic processing
por: Norris, Jade E., et al.
Publicado: (2015)

Eigenvector alignment: Assessing functional network changes in amnestic mild cognitive impairment and Alzheimer’s disease
por: Clark, Ruaridh A., et al.
Publicado: (2020)

Functional Innervation of Guinea-Pig Bladder Interstitial Cells of Cajal Subtypes: Neurogenic Stimulation Evokes In Situ Calcium Transients
por: Gray, Susannah M., et al.
Publicado: (2013)

Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle
por: McGahon, Mary K., et al.
Publicado: (2013)

CAMKII as a therapeutic target for growth factor–induced retinal and choroidal neovascularization
por: Ashraf, Sadaf, et al.
Publicado: (2019)

Insights on supporting the aging brain microvascular endothelium
por: Barabutis, Nektarios
Publicado: (2021)

A study of paired cadaver kidney transplants.
por: Middleton, D., et al.
Publicado: (1984)

Adiponectin accumulation in the retinal vascular endothelium and its possible role in preventing early diabetic microvascular damage
por: Sakaue, Taka-aki, et al.
Publicado: (2022)

Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine
por: McDowell, Rosemary E., et al.
Publicado: (2018)

Effects of a Mental Health Intervention in Athletes: Applying Self-Determination Theory
por: Shannon, Stephen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_j62fsq7pvpgusjv5u8ks1a0m15