IRF-5-Mediated Inflammation Limits CD8(+) T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection

Inflammation is known to be necessary for promoting, sustaining, and tuning CD8(+) T cell responses. Following experimental Leishmania donovani infection, the inflammatory response is mainly induced by the transcription factor IRF-5. IRF-5 is responsible for the activation of several genes encoding...

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Detalles Bibliográficos
Autores principales: Hammami, Akil, Charpentier, Tania, Smans, Mélina, Stäger, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457842/
https://www.ncbi.nlm.nih.gov/pubmed/26046638
http://dx.doi.org/10.1371/journal.ppat.1004938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457842/
https://www.ncbi.nlm.nih.gov/pubmed/26046638
http://dx.doi.org/10.1371/journal.ppat.1004938

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