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IRF-5-Mediated Inflammation Limits CD8(+) T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection
Inflammation is known to be necessary for promoting, sustaining, and tuning CD8(+) T cell responses. Following experimental Leishmania donovani infection, the inflammatory response is mainly induced by the transcription factor IRF-5. IRF-5 is responsible for the activation of several genes encoding...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457842/ https://www.ncbi.nlm.nih.gov/pubmed/26046638 http://dx.doi.org/10.1371/journal.ppat.1004938 |