Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor

Understanding the HIV integrase protein and mechanisms of resistance to HIV integrase inhibitors is complicated by the lack of a full length HIV integrase crystal structure. Moreover, a lentiviral integrase structure with co-crystallised DNA has not been described. For these reasons, we have develop...

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Detalles Bibliográficos
Autores principales: Quashie, Peter K., Han, Ying-Shan, Hassounah, Said, Mesplède, Thibault, Wainberg, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457863/
https://www.ncbi.nlm.nih.gov/pubmed/26046987
http://dx.doi.org/10.1371/journal.pone.0128310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457863/
https://www.ncbi.nlm.nih.gov/pubmed/26046987
http://dx.doi.org/10.1371/journal.pone.0128310

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