Febuxostat improves outcome in a rat model of cancer cachexia

BACKGROUND: Activity of xanthine oxidase is induced in cancer cachexia, and its inhibition by allopurinol or oxypurinol improves survival and reduces wasting in the Yoshida hepatoma cancer cachexia model. Here, we tested the effects of the second-generation xanthine oxidase inhibitor febuxostat comp...

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Detalles Bibliográficos
Autores principales: Konishi, Masaaki, Pelgrim, Loes, Tschirner, Anika, Baumgarten, Anna, von Haehling, Stephan, Palus, Sandra, Doehner, Wolfram, Anker, Stefan D, Springer, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458083/
https://www.ncbi.nlm.nih.gov/pubmed/26136193
http://dx.doi.org/10.1002/jcsm.12017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458083/
https://www.ncbi.nlm.nih.gov/pubmed/26136193
http://dx.doi.org/10.1002/jcsm.12017

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