4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors

Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic anti-tumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects of CD19 CARs relate to greater susceptibility of h...

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Detalles Bibliográficos
Autores principales: Long, Adrienne H., Haso, Waleed M., Shern, Jack F., Wanhainen, Kelsey M., Murgai, Meera, Ingaramo, Maria, Smith, Jillian P., Walker, Alec J., Kohler, M. Eric, Venkateshwara, Vikas R., Kaplan, Rosandra N., Patterson, George H., Fry, Terry J., Orentas, Rimas J., Mackall, Crystal L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458184/
https://www.ncbi.nlm.nih.gov/pubmed/25939063
http://dx.doi.org/10.1038/nm.3838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458184/
https://www.ncbi.nlm.nih.gov/pubmed/25939063
http://dx.doi.org/10.1038/nm.3838

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