Direct observation of TALE protein dynamics reveals a two-state search mechanism

Transcription activator-like effector (TALE) proteins are a class of programmable DNA-binding proteins for which the fundamental mechanisms governing the search process are not fully understood. Here we use single-molecule techniques to directly observe TALE search dynamics along DNA templates. We f...

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Detalles Bibliográficos
Autores principales: Cuculis, Luke, Abil, Zhanar, Zhao, Huimin, Schroeder, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458887/
https://www.ncbi.nlm.nih.gov/pubmed/26027871
http://dx.doi.org/10.1038/ncomms8277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458887/
https://www.ncbi.nlm.nih.gov/pubmed/26027871
http://dx.doi.org/10.1038/ncomms8277

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