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Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p

The ABC transporter Cdr1 protein (Cdr1p) of Candida albicans, which plays a major role in antifungal resistance, has two transmembrane domains (TMDs) and two nucleotide binding domains (NBDs) that are interconnected by extracellular (ECLs) and intracellular (ICLs) loops. To examine the communication...

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Detalles Bibliográficos
Autores principales: Shah, Abdul Haseeb, Rawal, Manpreet Kaur, Dhamgaye, Sanjiveeni, Komath, Sneha Sudha, Saxena, Ajay Kumar, Prasad, Rajendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459223/
https://www.ncbi.nlm.nih.gov/pubmed/26053667
http://dx.doi.org/10.1038/srep11211