Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models

Survivin is highly expressed in most human tumors and fetal tissue, and absent in terminally differentiated cells. It promotes tumor cell proliferation by negatively regulating cell apoptosis and facilitating cell division. Survivin's selective expression pattern suggests that it might be a sui...

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Detalles Bibliográficos
Autores principales: Chi, Yudan, Wang, Xiang, Yang, Yong, Zhang, Chao, Ertl, Hildegund C J, Zhou, Dongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459545/
https://www.ncbi.nlm.nih.gov/pubmed/25368912
http://dx.doi.org/10.1038/mtna.2014.59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459545/
https://www.ncbi.nlm.nih.gov/pubmed/25368912
http://dx.doi.org/10.1038/mtna.2014.59

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