Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

Formulation of short interfering RNA (siRNA) into multicomponent lipid nanoparticles (LNP) is an effective strategy for hepatic delivery and therapeutic gene silencing. This study systematically evaluated the effect of polyethylene glycol (PEG) density on LNP physicochemical properties, innate immun...

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Detalles Bibliográficos
Autores principales: Kumar, Varun, Qin, June, Jiang, Yongfeng, Duncan, Richard G, Brigham, Benjamin, Fishman, Shannon, Nair, Jayaprakash K, Akinc, Akin, Barros, Scott A, Kasperkovitz, Pia V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459547/
https://www.ncbi.nlm.nih.gov/pubmed/25405467
http://dx.doi.org/10.1038/mtna.2014.61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459547/
https://www.ncbi.nlm.nih.gov/pubmed/25405467
http://dx.doi.org/10.1038/mtna.2014.61

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