Preclinical Studies on Intestinal Administration of Antisense Oligonucleotides as a Model for Oral Delivery for Treatment of Duchenne Muscular Dystrophy

Antisense oligonucleotides (AONs) used to reframe dystrophin mRNA transcripts for Duchenne muscular dystrophy (DMD) patients are tested in clinical trials. Here, AONs are administered subcutaneously and intravenously, while the less invasive oral route would be preferred. Oral delivery of encapsulat...

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Detalles Bibliográficos
Autores principales: van Putten, Maaike, Young, Courtney, van den Berg, Sjoerd, Pronk, Amanda, Hulsker, Margriet, Karnaoukh, Tatyana G, Vermue, Rick, van Dijk, Ko Willems, de Kimpe, Sjef, Aartsma-Rus, Annemieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459548/
https://www.ncbi.nlm.nih.gov/pubmed/25405468
http://dx.doi.org/10.1038/mtna.2014.62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459548/
https://www.ncbi.nlm.nih.gov/pubmed/25405468
http://dx.doi.org/10.1038/mtna.2014.62

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