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Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy
BACKGROUND: Interaction of integrin β3 with c-Src plays critical roles in cellular signaling which is heavily implicated in platelet adhesion and aggregation, as well as in tumor cell proliferation and metastasis or in osteoclastic bone resorption. Selectively blocking integrin αIIbβ3 outside-in sig...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459659/ https://www.ncbi.nlm.nih.gov/pubmed/26025329 http://dx.doi.org/10.1186/s13045-015-0159-8 |